PE-22-28

PE-22-28 is a synthetic heptapeptide (GVSWGLR) derived from spadin, a naturally occurring peptide fragment from sortilin. This peptide functions as a potent antagonist of the TREK-1 potassium channel with dramatically improved specificity and affinity compared to its parent peptide (IC50 of 0.12 nM vs. 40-60 nM for spadin). Research demonstrates that PE-22-28 induces robust neurogenesis following just four days of treatment, with significant antidepressant effects in behavioral models and stimulation of both neurogenesis and synaptogenesis — ensuring newly generated cells mature into functional neurons. Its extended action duration (up to 23 hours vs. 7 hours for spadin) makes PE-22-28 a compelling research compound for investigating mood disorders and activity-dependent neuroplasticity.

10mg