Buy Selank: Anxiolytic Peptide for Neuroscience Research

Selank is a synthetic heptapeptide developed - like Semax - at the Institute of Molecular Genetics of the Russian Academy of Sciences. As a derivative of the endogenous immune peptide Tuftsin, Selank combines anxiolytic properties with nootropic activity and immunomodulatory potential - an unusual combination that makes it particularly interesting in neuroscience research.

Selankcognitive

Synthetic tuftsin analog with anxiolytic, nootropic, and immunomodulatory properties. Developed at the Russian Academy of Sciences.

What sets Selank apart from classical anxiolytics like benzodiazepines: it modulates the GABAergic system without the typical side effects - no sedation, no dependence, no cognitive impairment in the models studied.

What Is Selank?

Selank is a heptapeptide with the amino acid sequence:

Thr-Lys-Pro-Arg-Pro-Gly-Pro

It is a synthetic analogue of Tuftsin (Thr-Lys-Pro-Arg), a naturally occurring tetrapeptide found in the body as part of immunoglobulin G (IgG). Tuftsin is known as an endogenous immunomodulator - it activates phagocytes and modulates the innate immune response.

Selank extends the Tuftsin sequence with the C-terminal tripeptide Pro-Gly-Pro, which - as with Semax - significantly increases enzymatic stability and extends the biological half-life. This structural parallel is no coincidence: both peptides were developed at the same institute using the same stabilization strategy.

In Russia, Selank is approved as a medication for anxiety disorders and neurasthenia (0.15% nasal spray).

Why Is Selank Being Researched?

Key Studies

Kasian et al. (2016, Frontiers in Pharmacology): This study showed that Selank influences the expression of genes involved in GABAergic neurotransmission. The authors documented that Selank "possesses pronounced anxiolytic activity and acts as a stable neuropsychotropic, antidepressant and anti-stress drug that reduces aggression and anxiety reactions in various animal species."

Kozlovskii and Danchev (2002): Early work documented the anxiolytic effects of Selank in various animal models - elevated plus maze, open field and conflict test - without the sedating effects seen with benzodiazepines.

Zozulia et al. (2008, Zhurnal Nevrologii i Psikhiatrii): Clinical study on the efficacy of Selank in generalized anxiety disorders and neurasthenia. The authors evaluated Selank as an effective anxiolytic with a favorable side effect profile.

Ershov et al. (2013, Peptides): This study examined the temporal dynamics of inflammatory gene expression under Selank influence and demonstrated "pronounced anxiolytic and nootropic activity as well as remarkable antiviral activity" against influenza A (H3N2), herpes simplex (HSV-1 and HSV-2) and cytomegalovirus (CMV).

Semenova et al. (2020, Neurochemical Journal): This work compared the nootropic and anxiolytic effects of Selank, Semax and Noopept by route of administration and showed that anxiolytic efficiency was higher with intraperitoneal injection while nootropic efficiency was more pronounced with intranasal administration.

Mechanisms of Action

Selank acts through multiple neurobiological systems:

GABAergic Modulation: The primary anxiolytic mechanism. Selank influences the expression of genes involved in GABA-A receptor subunit composition. It enhances GABAergic transmission without acting directly at the benzodiazepine binding site - hence the absence of sedation and dependence.
Monoamine Modulation: Selank affects the metabolism of serotonin and noradrenaline, particularly degradation by enkephalinase. This contributes to its antidepressant and mood-stabilizing effects.
Immunomodulation: As a Tuftsin derivative, Selank retains immunomodulatory properties. It activates phagocytes, modulates cytokine expression and shows antiviral activity against multiple virus families.
BDNF Expression: Like Semax, Selank also influences BDNF expression, though through different signaling pathways and with a different temporal profile. The nootropic component of Selank is partly attributed to this neurotrophin modulation.
Inflammatory Modulation: Selank regulates the expression of genes involved in the inflammatory response, contributing to both its anxiolytic and immunomodulatory effects.

Quality Criteria When Purchasing

HPLC Purity ≥98%: Research-grade standard.
Mass Spectrometry: Identity confirmation of the exact sequence and molecular mass.
Janoshik Verification: Independent testing of every batch at PeptidesDirect.
Peptide Content: Net peptide content after deducting counterions, residual moisture and TFA.

Dosages in Research Literature

Intranasal Administration: The standard route in Russian studies. The approved product in Russia is a 0.15% nasal spray. Typical research dosages range from 250-500 µg intranasally.

Intraperitoneal/Subcutaneous Administration: In animal models, dosages of 100-300 µg/kg are used. Semenova et al. showed that the anxiolytic effect is more pronounced with systemic administration than with intranasal delivery.

These figures are from published research literature and do not constitute dosage recommendations.

Storage

Selank is supplied as lyophilized powder:

Before Reconstitution: Store at -20 °C. Stable for months.
After Reconstitution: Store at 2-8 °C in the refrigerator. Use within 2-4 weeks.
Reconstitution: Perform with bacteriostatic water. Gently swirl, do not shake.
Light Protection: Store protected from light.

Why Buy Selank from PeptidesDirect?

Janoshik-verified: Independent analytics for every batch.
Two Sizes: 10 mg (€29.99) and 30 mg (€79.99).
EU Shipping: No customs, no import fees. Delivery in 2-3 business days with tracking.
Research-Grade Quality: ≥98% purity.

Frequently Asked Questions

What is Selank used for? Internationally, exclusively for in vitro and preclinical research. In Russia, Selank is approved as a medication for anxiety disorders.

Is Selank a benzodiazepine? No. Selank modulates the GABAergic system but does not bind to the benzodiazepine binding site of the GABA-A receptor. The typical benzodiazepine side effects are absent: no sedation, no dependence, no retrograde amnesia in the models studied.

How does Selank differ from Semax? Selank is primarily anxiolytic (GABA modulation, anxiety reduction), Semax is primarily nootropic (BDNF enhancement, cognitive improvement). Selank additionally has immunomodulatory and antiviral properties. Both were developed at the same institute and share the Pro-Gly-Pro stabilization strategy.

Can Selank be combined with Semax? In research, both peptides are frequently studied as complementary agents. A study by Kost et al. (2020, Behavioural Brain Research) examined the effects of both peptides on functional connectivity in 52 healthy subjects. PeptidesDirect also offers a ready-made Semax/Selank Mix.

Are there human studies on Selank? Yes. Clinical studies on efficacy in generalized anxiety disorders exist in Russia (Zozulia et al., 2008). The study by Kost et al. (2020) examined the effects on functional connectivity in healthy subjects using fMRI.

Selankcognitive

Synthetic tuftsin analog with anxiolytic, nootropic, and immunomodulatory properties. Developed at the Russian Academy of Sciences.