LL-37

LL-37 is a 37-amino acid cathelicidin antimicrobial peptide derived from human immune cells with potent broad-spectrum antimicrobial activity through multiple mechanisms. The peptide binds to negatively charged bacterial membranes through positive charge-mediated interaction, leading to transmembrane pore formation, membrane disruption, and cell lysis. Beyond direct membrane disruption, LL-37 penetrates bacterial cells to interact with intracellular targets and disrupts bacterial DNA transcription and translation. Research demonstrates effectiveness against over 38 bacterial species, 16 fungi, and 16 viruses, with investigations expanding into modified LL-37 analogs designed to improve proteolytic stability and therapeutic potential.

5mg