KPV
Anti-inflammatory tripeptide derived from alpha-MSH (positions 11-13). Inhibits NF-kB signaling, supports gut barrier integrity, and shows antimicrobial activity. A targeted approach to inflammation research without broad immunosuppression.
€49.99
€59.99
Save 17%10mg
What is KPV?
KPV (Lys-Pro-Val) is a naturally occurring tripeptide derived from the C-terminal fragment (positions 11-13) of alpha-melanocyte-stimulating hormone (alpha-MSH). It retains the potent anti-inflammatory signaling of the parent hormone without its melanogenic (skin-darkening) effects. KPV acts primarily by inhibiting NF-kB activation and reducing pro-inflammatory cytokine production.
Why It Matters
One of the most promising anti-inflammatory peptides in current research. KPV targets the master inflammatory switch NF-kB directly, reducing IL-1beta, TNF-alpha, and IL-6 without broadly suppressing the immune system. Especially interesting for gut barrier and wound healing research.
Key Research Areas
- Anti-inflammatory - inhibits NF-kB activation and reduces pro-inflammatory cytokines (IL-1beta, TNF-alpha, IL-6)
- Gut barrier support - restores epithelial barrier integrity in murine colitis models, reduces intestinal inflammation
- Antimicrobial - direct activity against Staphylococcus aureus and Candida albicans
- Wound healing - accelerates wound closure and reduces inflammation at wound sites in preclinical models
- Immunomodulatory - modulates macrophage and dendritic cell activity without broad immunosuppression
Specifications
- Sequence: Lys-Pro-Val (tripeptide)
- Purity: ≥98% (HPLC verified)
- Form: Lyophilized powder
- Storage: 2-8°C after reconstitution, use within 4 weeks
- CoA: Included
Related: BPC-157 | TB-500 | LL-37
For Research Purposes Only.
