Name: DSIP
Brand: PeptidesDirect
SKU: PD-DSIP-10MG
Price: 39.99 EUR
Availability: InStock

Question 1

What is DSIP?

Accepted Answer

DSIP is a nonapeptide with the sequence Trp-Ala-Gly-Gly-Asp-Ala-Ser-Gly-Glu, first isolated in 1977 from the blood of rabbits showing delta-wave EEG activity, which is where the name Delta Sleep-Inducing Peptide comes from. The published work on it is largely rodent research measuring HPA-axis markers such as hypothalamic substance P, antioxidant enzyme activity, and pharmacokinetics. No DSIP gene or receptor has ever been identified. We supply it as a research-grade lyophilized powder for laboratory use only.

Question 2

How should I store DSIP?

Accepted Answer

Lyophilized DSIP is commonly kept at -20°C for longer storage or at 2-8°C (refrigerator) for short-term storage. After reconstitution, the usual laboratory convention is refrigeration at 2-8°C and use within about 30 days; this is standard peptide-handling practice, not a stability result measured for this product. Avoid repeated freeze-thaw cycles.

Question 3

What purity is your DSIP?

Accepted Answer

Every batch of DSIP ships with a certificate of analysis from Janoshik Analytical, an independent third-party laboratory, at a minimum purity of 99%. We do not run a lab ourselves: the manufacturer commissions this test, and we pass the report on unchanged, with an online verification link on the product page. This batch also carries a second, independent test from Kovera Labs, commissioned outside the manufacturer.

Question 4

How do I reconstitute DSIP?

Accepted Answer

Add bacteriostatic water slowly along the inside wall of the vial. Do not shake - gently swirl until the powder is fully dissolved. Typical reconstitution uses 1-2 mL of bacteriostatic water per vial. Allow the solution to clear before use.

Question 5

Does DSIP have a known receptor or mechanism, or is that still unresolved?

Accepted Answer

Unresolved. Despite the peptide's name and nearly fifty years of study, no DSIP gene and no single confirmed receptor have ever been identified, and a 2006 review in the Journal of Neurochemistry describes the core factor hypothesis as still unresolved (PMID 16539679). That review even notes the possibility that a different, DSIP-like peptide rather than DSIP itself accounts for some of the readouts reported in older animal studies. Every published observation for this peptide should be read against that unresolved mechanism, because there is no defined receptor to explain it.

Question 6

Is DSIP approved by the FDA, EMA, or any other regulator?

Accepted Answer

No. DSIP holds no marketing authorisation from the EMA or the FDA and carries no regulatory clearance for human or animal use. Under the name Emideltide it was listed on the FDA's 503A Category 2 list for substances with significant safety concerns; an updated list published 15 April 2026 removed Emideltide from Category 2 effective 22 April 2026, after its sponsors withdrew their petition ahead of review. Removal from Category 2 is not a compounding clearance by itself: the FDA's Pharmacy Compounding Advisory Committee reviewed DSIP at its 23-24 July 2026 meeting, and only addition to the 503A bulks list would open a compounding path. In the EU, DSIP has no medicinal approval and is supplied strictly for laboratory research.

Question 7

Why does DSIP disappear from the blood so fast, and does that matter for the research?

Accepted Answer

DSIP is cleared from plasma in minutes: an enzyme-immunoassay study measured intravenous half-lives of 4.0 minutes in dogs, 2.9 minutes in monkeys and 2.0 minutes in rats, with a clearance rate of about 30.7 ml/kg per minute in dogs (PMID 6379493). That is far shorter than the multi-hour readouts reported in the older literature, which is one of the reasons the underlying mechanism is still considered unresolved: whatever produces a downstream effect does not appear to require the parent peptide to remain in circulation. No published study has tested whether an active metabolite or a different delivery approach changes this picture.

Question 8

Is Emideltide a different peptide from DSIP, or just another name for it?

Accepted Answer

No, Emideltide is just the pharmaceutical name FDA documents use for DSIP; both the acetate and free-base salt forms fall under that single name. When you see Emideltide in an FDA 503A list, a PCAC agenda, or a compounding-pharmacy bulletin, it is referring to the same nonapeptide sold here as a research chemical, not a related but different substance.

Question 9

Is DSIP being reviewed by the FDA together with other peptides right now?

Accepted Answer

That review has already taken place. DSIP was reviewed at the FDA's Pharmacy Compounding Advisory Committee meeting on 23-24 July 2026, on the same agenda as Epitalon and Semax, part of the broader evaluation that also removed twelve peptides, DSIP included, from 503A Category 2 in April 2026 after their sponsors withdrew safety petitions. That grouping does not mean the three peptides share a mechanism or an evidence base, only that they are moving through the same FDA compounding process on the same calendar date.

Question 10

What does your own lab report show for a specific DSIP batch, and how do I check it myself?

Accepted Answer

The two most recent batches we've published show 99.52% purity and 10.18 mg content for batch DSP10626A, Clear cap, tested by Kovera Labs, and 99% purity and 11.94 mg content for the Yellow batch, tested by Janoshik. The Kovera report is community-submitted, not commissioned by the manufacturer and not paid for by us; the Janoshik report is commissioned by the manufacturer, and we publish it unchanged. Both can be checked directly, the Kovera result at koveralabs.com/#/verify and the Janoshik result at verify.janoshik.com, both linked from the batch's certificate of analysis on our lab reports page.

DSIP

What is DSIP

How it works

Documentation

Storage and stability

Reviews

Frequently Asked Questions

Technical data sheet

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