MOTS-c

MOTS-c is a 16-amino acid mitochondrial-derived peptide encoded from the 12S rRNA region of mitochondrial DNA that functions as an exercise mimetic with significant metabolic effects. In response to physical activity, MOTS-c levels increase nearly 12-fold in muscle cells and approximately 50% in blood plasma, serving as a molecular signal linking exercise to systemic benefits. This peptide stimulates glucose utilization, enhances fat oxidation, reduces inflammation, and improves insulin sensitivity through increased beta-oxidation and prevention of lipid accumulation. Research in aged mice demonstrates that intermittent MOTS-c treatment significantly increases physical capacity and healthspan.

40mg