TB-500 is a synthetic version of Thymosin Beta-4, a naturally occurring peptide found in nearly all human and animal cells. It is a 43-amino acid peptide studied extensively in research for its role in tissue repair and cellular migration.

How should I store TB-500?

Store lyophilized TB-500 at -20°C for long-term storage or at 2-8°C (refrigerator) for short-term use. After reconstitution, keep refrigerated and use within 30 days. Protect from light and avoid freeze-thaw cycles.

What purity is your TB-500?

Our TB-500 is third-party tested by Janoshik Analytical with verified purity of 98% or higher. A certificate of analysis is available for each batch on the product page.

How do I reconstitute TB-500?

Add bacteriostatic water slowly along the vial wall. Gently swirl to dissolve - never shake. Use 1-2 mL of bacteriostatic water per vial. The solution should be clear before use.

Buy TB-500 - Thymosin Beta-4, Janoshik-Tested

Name: TB-500
Brand: PeptidesDirect
SKU: PD-TB500-10MG
Price: 39.99 EUR
Availability: InStock

Active fragment of Tβ4

TB-500 is the short, synthetic version of the most active region of thymosin beta-4. The full protein is 43 amino acids long, but most of its repair signal is concentrated in this small fragment.

Actin organizer

Binds G-actin, the building block of the cellular skeleton. By managing the actin pool, it lets cells reshape themselves and move toward damaged tissue in laboratory studies.

Cell migration signal

Triggers cells like fibroblasts, endothelial cells, and stem cells to migrate into wound sites, the first step of tissue repair in cell-culture and animal models.

New blood vessels

Promotes angiogenesis. New capillaries deliver oxygen and nutrients to healing tissue, a recurring finding in cardiac and skin repair research.

Anti-inflammatory and anti-fibrotic

Lowers pro-inflammatory mediators and reduces excessive scar-forming pathways in animal studies, helping tissue heal cleanly instead of stiffening.

Cornea and surface tissue

A long line of eye research shows the peptide accelerates closure of corneal wounds and dampens infection-driven inflammation in laboratory models.

Research areas

Tissue repairCell migrationAngiogenesisAnti-inflammatoryCornea & skin

What is TB-500

TB-500 is a synthetic peptide that copies the active core region of thymosin beta-4 (Tβ4), a small protein found throughout the body. While the full Tβ4 molecule is 43 amino acids long, most of its repair activity sits inside a short stretch around the Ac-LKKTETQ sequence. TB-500 is built around that fragment, which makes it cheaper and easier to manufacture while keeping the key biological signal that researchers care about.

We supply it in lyophilized (freeze-dried) form, the same format used in published protocols.

How it works

TB-500 acts on the cellular skeleton. It binds to G-actin, the monomer that cells use to assemble and reshape their internal scaffolding. By managing this pool of actin, the peptide lets cells change shape, crawl toward injured tissue, and rebuild what is missing. This single mechanism feeds into a wide range of repair processes: fibroblasts close skin wounds, endothelial cells form new capillaries, and progenitor cells move into damaged tissue.

The peptide also calms inflammation and pushes back against fibrosis. In animal models of cardiac injury, eye infection, and skin wounding, it lowers inflammatory mediators and reduces the excessive scar tissue that often follows damage. The combination of cell-migration signal, angiogenesis, and softer scarring is what gives TB-500 its reputation as a broad regenerative research tool.

Often studied alongside

The most popular pairing in regenerative-peptide research is TB-500 plus BPC-157, sometimes called the "Wolverine Stack" in informal labs. The two peptides act through different mechanisms: TB-500 mobilizes cells through actin, while BPC-157 supports growth-factor signaling and blood-vessel formation. Many independent research groups examine them together when modeling complex injuries.

Most common research partner for TB-500

BPC-157regeneration

Gastric pentadecapeptide (15 amino acids) known for exceptional tissue repair properties. Promotes wound healing, angiogenesis, and cytoprotection across tendons, muscles, gut, and nerves. Over 30 years of preclinical research.

For convenience, a pre-mixed combination vial is also available.

Pre-blended BPC-157 and TB-500 in a single vial

WOLVERINE (BPC-157 + TB-500)regeneration

The Wolverine Stack: BPC-157 (5mg) + TB-500 (5mg) combined in one vial. The most researched healing peptide duo for tissue repair, tendon recovery, and systemic regeneration. Batch-specific Janoshik COA.

For reconstitution, the standard solvent in published protocols is bacteriostatic or sterile water.

Standard solvent for reconstitution

Bacteriostatic Wateraccessories

USP-grade sterile water with 0.9% benzyl alcohol - the standard solvent for reconstituting lyophilized peptides. Essential accessory for any peptide research. Each vial is sealed and ready to use.

Documentation

Material specification

Purity

≥98% (HPLC verified)

Test method

HPLC + mass spectrometry

Form

Lyophilized powder

Storage (sealed)

2 to 8 °C, light-protected

Storage (reconstituted)

2 to 8 °C, use within 4 weeks

CoA

Batch-specific, third-party (Janoshik)

Lab Report (COA)

Batch NumberWhite

Purity99.40%

Testing LabJanoshik

Test Date8 Dec 2025

Download COA

Selected research

Research use only

This material is sold strictly for in-vitro research and laboratory use. Not intended for human or animal consumption, medical, cosmetic, or household applications. Suitable only for professional laboratory environments.