Ipamorelin is a selective growth hormone secretagogue peptide that stimulates the pituitary gland. It is a pentapeptide (5 amino acids) studied for its highly selective action on growth hormone release without significantly affecting cortisol or prolactin levels.

How should I store Ipamorelin?

Store lyophilized Ipamorelin at -20°C for long-term storage or at 2-8°C for short-term use. Once reconstituted, keep refrigerated at 2-8°C and use within 30 days. Protect from light.

What purity is your Ipamorelin?

Our Ipamorelin is independently tested by Janoshik Analytical with verified purity of 98% or higher. A certificate of analysis accompanies each batch.

How do I reconstitute Ipamorelin?

Add bacteriostatic water slowly along the inside wall of the vial. Gently swirl - never shake. Use 1-2 mL of bacteriostatic water. The peptide should dissolve quickly into a clear solution.

Buy Ipamorelin - GHRH Peptide, Janoshik-Tested

Name: Ipamorelin
Brand: PeptidesDirect
SKU: PD-IPAMORELIN-10MG
Price: 39.99 EUR
Availability: InStock

Selective GH secretagogue

Ipamorelin is a five-amino-acid peptide that triggers a clean pulse of growth hormone in research models, without spilling over into other hormone systems.

Ghrelin-receptor agonist

The peptide locks onto GHS-R1a, the ghrelin receptor on pituitary cells, mimicking how the body's own ghrelin signal asks for a GH release.

Pulsatile, not flat

Studies show short-lived spikes of GH that mirror the body's natural pulse pattern, rather than a constant elevated baseline.

No cortisol or prolactin spike

Unlike GHRP-6 and hexarelin, ipamorelin does not raise ACTH, cortisol, or prolactin in published studies, which is the trait that earned it the label "first selective GH secretagogue".

Bone formation research

Counteracted glucocorticoid-induced bone loss and supported longitudinal bone growth in rat studies.

Gut motility studies

Investigated for postoperative ileus in rodent models and a phase-2 human bowel-resection trial as a ghrelin-receptor agonist on intestinal transit.

Research areas

GH secretagogueGhrelin receptorBone formationGut motilityEndocrine signaling

What is Ipamorelin

Ipamorelin is a synthetic pentapeptide, designed in the late 1990s as a selective agonist of the growth-hormone secretagogue receptor (GHS-R1a), the same receptor that the gut hormone ghrelin binds to. The five-amino-acid sequence is Aib-His-D-2-Nal-D-Phe-Lys-NH2.

It became known in the literature as the first GH secretagogue with a clean hormone profile: in the original characterization study, ipamorelin released growth hormone with a potency comparable to GHRP-6, but did not raise ACTH or cortisol above the baseline seen with natural GHRH stimulation.

We supply ipamorelin as a lyophilized (freeze-dried) powder, the same form used in published research protocols.

How it works

Ipamorelin docks onto the GHS-R1a receptor on pituitary somatotrophs, the cells that store and release growth hormone. That signal triggers a short, pulsatile release of GH, similar to how the body's own ghrelin works during fasting. The effect is dose-responsive and well characterized in human pharmacokinetic-pharmacodynamic modeling.

What sets ipamorelin apart in research is its receptor selectivity. Older GH-releasing peptides such as GHRP-6 and hexarelin also bump up ACTH, cortisol, and prolactin, which complicates the interpretation of any GH-driven effect. Ipamorelin avoids that crosstalk: in the foundational studies it released GH cleanly, with no significant change in ACTH, cortisol, prolactin, FSH, LH, or TSH.

Beyond the GH axis, the same ghrelin-receptor binding has been studied in two other contexts: bone formation, where ipamorelin counteracted glucocorticoid-induced bone loss in adult rats, and gastrointestinal motility, where the peptide accelerated intestinal transit in rodent postoperative-ileus models and was later tested in a phase-2 human bowel-resection trial.

Often studied alongside

In growth-hormone-axis research, ipamorelin is most often paired with CJC-1295, a long-acting GHRH analog. The two peptides act on different receptors (GHS-R for ipamorelin, GHRH-R for CJC-1295) and the combination is studied for the synergistic GH pulse it produces. Pre-mixed blends of the two are commonly used to keep dosing ratios consistent across studies.

Pre-mixed GH-axis combination used in synergy research

CJC-1295/Ipamorelin (No-DAC)growth

2-in-1 growth hormone blend: CJC-1295 no-DAC (Modified GRF 1-29, 5 mg) + Ipamorelin (5 mg) combined in one vial. The CJC-1295 component is the short-acting no-DAC variant (about 30 minute half-life), not the long-acting DAC form. Stimulates natural GH release through two different pathways for amplified, more physiological growth hormone pulses.

GHRH analog studied as an alternative pairing partner

Sermorelingrowth

GHRH(1-29) analog for physiological growth hormone stimulation research

Recombinant growth hormone, the direct comparator in GH-axis work

For reconstitution, the standard solvent in published protocols is bacteriostatic or sterile water.

Standard solvent for reconstitution

Bacteriostatic Wateraccessories

USP-grade sterile water with 0.9% benzyl alcohol - the standard solvent for reconstituting lyophilized peptides. Essential accessory for any peptide research. Each vial is sealed and ready to use.

Documentation

Material specification

Purity

≥98% (HPLC verified)

Test method

HPLC + mass spectrometry

Form

Lyophilized powder

Storage (sealed)

2 to 8 °C, light-protected

Storage (reconstituted)

2 to 8 °C, use within 4 weeks

CoA

Batch-specific, third-party (Janoshik)

Lab Report (COA)

Batch NumberRed Cap

Purity99.73%

Testing LabJanoshik

Test Date7 Nov 2025

Download COA

Selected research

Research use only

This material is sold strictly for in-vitro research and laboratory use. Not intended for human or animal consumption, medical, cosmetic, or household applications. Suitable only for professional laboratory environments.