IGF-1 LR3
Long R3 variant of Insulin-like Growth Factor 1, modified for reduced IGFBP binding and ~20-30 hour half-life. Researched for cell proliferation, hypertrophy, and metabolic signaling. ≥98% purity.
€74.99
1mg
Payment Methods
What is IGF-1 LR3?
IGF-1 LR3 (Long R3 Insulin-like Growth Factor 1) is an 83-amino-acid modified analog of native IGF-1. Two key modifications, an arginine substitution at position 3 and a 13-amino-acid N-terminal extension, reduce binding to IGF-binding proteins (IGFBPs) and extend the circulating half-life to approximately 20 to 30 hours, compared to roughly 20 minutes for native IGF-1.
Why It Matters
Native IGF-1 is rapidly sequestered by IGFBPs in vivo, limiting its utility in research. The LR3 variant's 2 to 3 times higher bioactivity and markedly extended half-life make it the preferred IGF-1 analog in cell culture, hypertrophy, and metabolic signaling studies.
Key Research Areas
- Cell proliferation - mitogenic signaling across multiple cell lines in vitro
- Muscle research - satellite cell activation, hypertrophy pathways, and protein synthesis
- Metabolic signaling - insulin receptor cross-talk and glucose uptake models
- Neuroprotection - IGF-1 receptor-mediated cellular survival studies
Product Specifications
- 83 amino acids, ~9.1 kDa
- Purity: ≥98% HPLC verified
- Independent Janoshik Analytical certificate of analysis
- Lyophilized powder, for research use only
