Référence des doses issues d'études
24 peptides avec des doses issues d'études publiées : 3 d'entre eux disposent d'une dose humaine établie, les 21 restants n'ont pas de protocole humain établi.
Il s'agit des doses utilisées dans des ÉTUDES PUBLIÉES, compilées comme référence de recherche neutre. La plupart de ces composés sont expérimentaux et n'ont AUCUN protocole de dosage humain établi ou approuvé ; pour beaucoup, toutes les doses quantifiées proviennent exclusivement d'études animales (mg/kg). Il s'agit d'une information de référence, pas d'une recommandation de dosage ni d'un avis médical.
Nous publions les doses utilisées dans les études, qui sont majoritairement des doses de recherche animale par kilogramme de poids corporel. Ce n'est volontairement pas la même chose que les quantités fixes en milligrammes qui circulent dans les communautés en ligne. Nous ne publions pas de protocoles d'auto-administration.
Dernière mise à jour : 8 juillet 2026
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24
Peptides recensés
3
Avec dose humaine établie
8 juillet 2026
Dernière mise à jour
Dose utilisée dans les études
0.25 mg per knee (rabbit, intra-articular) -> 0.5 mg/kg/day (rat, oral)
mixed (mg/kg/day animal systemic + absolute mg per joint; two studies unquantified)
Discuté dans les communautés de recherche* 300-500 mcg/day (SC)
Voies d'administration
All quantified doses in the listed studies are preclinical (rat 0.5 mg/kg/day oral, rabbit 0.25 mg/knee intra-articular); two mouse studies gave no per-kg dose, and the human obesity trials mentioned (oral 0.25 to 30 mg/day) were negative, discontinued, and not PubMed-indexed, so there is no established human protocol.
- PMID 11146367Ng FM et al. Metabolic studies of a synthetic lipolytic domain (AOD9604) of human growth hormone. Horm Res. 2000 (obese Zucker rats, 0.5 mg/kg/day oral)
- PMID 11673763Heffernan MA et al. Increase of fat oxidation and weight loss in obese mice... modified C-terminal fragment. Int J Obes Relat Metab Disord. 2001 (ob/ob mice, SC osmotic pump, dose not stated)
- PMID 11713213Heffernan M et al. Effects of human GH and its lipolytic fragment (AOD9604) on lipid metabolism... beta(3)-AR knock-out mice. Endocrinology. 2001 (IP, dose not stated)
- PMID 26275694Kwon DR, Park GY. Intra-articular AOD9604 with or without Hyaluronic Acid in Rabbit Osteoarthritis Model. Ann Clin Lab Sci. 2015 (0.25 mg/knee, intra-articular)
- PMID 25208511Cox HD et al. Detection and in vitro metabolism of AOD9604. Drug Test Anal. 2015 (in vitro, 50 pg/mL assay LOD)
- PMID 15134286Wilding J. AOD-9604 (Metabolic). Curr Opin Investig Drugs. 2004 (program review, extra source)
- PMID 41490200Rahman OF et al. Therapeutic Peptides in Orthopaedics. J Am Acad Orthop Surg Glob Res Rev. 2026 (brief mention, extra source)
Dose utilisée dans les études
10 pg/kg per dose (rat) -> 2 mg/kg (dog, safety/tox study)
per-kg body weight (animal); efficacy in ug/kg, ng/kg, pg/kg; safety up to mg/kg
Discuté dans les communautés de recherche* 250-500 mcg/day (SC)
Voies d'administration
Reference only, not a recommendation: every numeric dose in the listed studies is animal (almost all rat) and spans many orders of magnitude (10 pg/kg to 2 mg/kg across efficacy and safety models); there is no established or approved human dosing protocol.
- PMID 16583442Krivic A, et al. Achilles detachment in rat and BPC 157: tendon-to-bone healing. J Orthop Res. 2006 (10 ug/kg, 10 ng/kg, 10 pg/kg IP).
- PMID 20225319Cerovecki T, et al. BPC 157 (PL 14736) improves ligament healing in the rat. J Orthop Res. 2010 (IP 10 ng/kg; topical 1.0 ug/g; oral 0.16 ug/mL).
- PMID 34829776Japjec M, et al. BPC 157 for disabled myotendinous junctions in rats. Biomedicines. 2021 (IP 10 ug/kg or 10 ng/kg; oral 0.16 ug/mL or 0.16 ng/mL).
- PMID 15052688Xue XC, et al. Protective effects of BPC 157 on gastric ulcer in rats. World J Gastroenterol. 2004 (200/400/800 ng/kg IM or intragastric).
- PMID 19903499Gjurasin M, et al. BPC 157 in traumatic nerve injury. Regul Pept. 2010 (10 ng/kg; 10 ug arm basis unspecified).
- PMID 32334036Xu C, et al. Preclinical safety evaluation of BPC-157. Regul Toxicol Pharmacol. 2020 (multi-species; up to 2 mg/kg in dogs, oral + IM).
- PMID 40131143IV BPC-157 safety pilot in 2 healthy adults, up to 20 mg (extra source, 2024-2026).
- PMID 40789979Peer-reviewed review: robust preclinical data, only 3 small human pilots, still investigational (extra source).
- ClinicalTrials.gov NCT07437547First registered efficacy trial: Phase 2 RCT in acute grade II hamstring strain, no results yet.
Dose utilisée dans les études
0.16 mg/week (SC, human) -> 4.5 mg/week (SC, human)
mixed: fixed mg per week (human trials), nmol/kg per day (mouse)
Discuté dans les communautés de recherche* 0.6-2.4 mg/week (SC)
Voies d'administration
Doses shown are those used in published studies for reference only, not a recommendation; cagrilintide is investigational (not an approved medicine), so there is no established human protocol.
- PMID 34798060Lau DCW, et al. Once-weekly cagrilintide dose-finding phase 2 trial (0.3-4.5 mg/wk SC). Lancet 2021;398(10317):2160-2172.
- PMID 33894838Enebo LB, et al. Cagrilintide (0.16-4.5 mg/wk SC) + semaglutide 2.4 mg phase 1b. Lancet 2021;397(10286):1736-1748.
- PMID 37364590Frias JP, et al. Cagrilintide 2.4 mg + semaglutide 2.4 mg in T2D phase 2. Lancet 2023;402(10403):720-730.
- PMID 40544433Garvey WT, et al. Cagrilintide 2.4 mg + semaglutide 2.4 mg (REDEFINE 1). N Engl J Med 2025;393(7):635-647.
- PMID 40544432Davies MJ, et al. Cagrilintide-semaglutide in T2D (REDEFINE 2). N Engl J Med 2025;393(7):648-659.
- PMID 40609154Oliveira Carvas A, et al. Cagrilintide 0.3/3/30 nmol/kg/day SC, mouse mechanistic. EBioMedicine 2025.
Dose utilisée dans les études
30 mcg/kg (CJC-1295 with DAC) -> 90 mcg/kg (CJC-1295 with DAC)
mixed: mcg/kg (human, DAC form only), flat mcg/animal (mouse, DAC form only)
Discuté dans les communautés de recherche* 100-200 mcg/day (no-DAC, the form we sell) or 1-2 mg/week (DAC, which we do not sell), SC
Voies d'administration
Reference only: the human figures (30 to 90 mcg/kg SC) are for CJC-1295 WITH DAC, the long-acting, albumin-conjugated form we do not sell. Our no-DAC product (Mod GRF 1-29, the short-acting form we sell) has no dedicated controlled human trial; its pharmacology is inferred from the sermorelin class. Applying the DAC trial's dose to a no-DAC vial would describe a molecule with a 5.8 to 8.1-day half-life for a product that clears in about 30 minutes. The mouse figure (flat 2 mcg per animal) is also from the DAC form. CJC-1295 has no approved or established human therapeutic dose.
- PMID 16352683Teichman SL et al. Prolonged stimulation of GH and IGF-I secretion by CJC-1295, a long-acting analog of GH-releasing hormone, in healthy adults. J Clin Endocrinol Metab. 2006;91(3):799-805. (human Phase 1, 0.03 to 0.06 mg/kg SC)
- PMID 17018654Ionescu M, Frohman LA. Pulsatile secretion of GH persists during continuous stimulation by CJC-1295, a long-acting GHRH analog. J Clin Endocrinol Metab. 2006;91(12):4792-7. (human, 0.06 to 0.09 mg/kg SC)
- PMID 16822960Alba M et al. Once-daily administration of CJC-1295 normalizes growth in the GHRH knockout mouse. Am J Physiol Endocrinol Metab. 2006;291(6):E1290-4. (mouse, flat 2 mcg per animal SC)
- PMID 15817669Jette L et al. hGRF(1-29)-albumin bioconjugates activate the GRF receptor in rats: identification of CJC-1295. Endocrinology. 2005;146(7):3052-8. (rat pharmacology, no per-kg dose in abstract)
- PMID 30489688Timms M et al. An immuno PCR screen for CJC-1295 and other GHRH analogs in equine plasma. Drug Test Anal. 2019;11(6):804-812. (equine anti-doping assay, no per-kg dose in abstract)
Dose utilisée dans les études
25 nmol/kg (~21 mcg/kg, human IV) -> 1 to 2 mg IV absolute (multi-species PK)
mixed (human nmol/kg, rat nmol/kg or mcg per 100 g, PK study absolute mg)
Discuté dans les communautés de recherche* 100-300 mcg (SC, evening)
Voies d'administration
Reference doses used in studies only, not a recommendation. The single human study is a small acute IV trial (6 insomniacs at 25 nmol/kg); the rest is rodent and multi-species animal work, so units differ (nmol/kg, mcg per 100 g, absolute mg) and no established human protocol exists.
- PMID 7028502Schneider-Helmert & Schoenenberger, 1981 (human insomnia, 25 nmol/kg IV)
- PMID 1382246Salieva et al., 1992 (rat HPA stress, 60 and 120 nmol/kg IP)
- PMID 11421812Shustanova et al., 2001 (rat oxidative stress, 12 mcg/100 g IP)
- PMID 21809625Bondarenko et al., 2011 (rat ageing, 10 mcg/100 g SC)
- PMID 6379493Kato et al., 1984 (dog/monkey/rat PK, 1 to 2 mg IV)
- PMID 16539679Kovalzon & Strekalova, 2006 (review: no DSIP gene/receptor)
Dose utilisée dans les études
0.1 microgram per rat per injection (approx 0.4 micrograms/kg) -> 1.0 microgram per mouse per injection (approx 40 micrograms/kg)
per-animal micrograms (in vivo, per-kg is an approximation from standard lab weights); micrograms/mL concentration (in vitro)
Discuté dans les communautés de recherche* 5-10 mg/day (SC)
Voies d'administration
All doses are preclinical: rodent (per-animal micrograms, subcutaneous) plus in-vitro cell culture, with no established or validated human dosing protocol for the tetrapeptide (the human "geroprotector" data come from Epithalamin, a different pineal extract).
- PMID 14501183Anisimov VN et al. Effect of Epitalon on biomarkers of aging, life span and spontaneous tumor incidence in female Swiss-derived SHR mice. Biogerontology. 2003;4(4):193-202.
- PMID 18856211Vinogradova IA et al. Effect of Ala-Glu-Asp-Gly peptide on life span and development of spontaneous tumors in female rats under different illumination regimes. Bull Exp Biol Med. 2007;144(6):825-30.
- PMID 12049808Anisimov VN et al. Inhibitory effect of peptide Epitalon on colon carcinogenesis induced by 1,2-dimethylhydrazine in rats. Cancer Lett. 2002;183(1):1-8.
- PMID 32019204Khavinson V et al. AEDG Peptide (Epitalon) Stimulates Gene Expression and Protein Synthesis during Neurogenesis. Molecules. 2020;25(3):609.
- PMID 12937682Khavinson VKh et al. Epithalon peptide induces telomerase activity and telomere elongation in human somatic cells. Bull Exp Biol Med. 2003;135(6):590-2.
Dose utilisée dans les études
10^-12 M (1 pM, in vitro); 0.2 mg/kg/day (lowest per-kg, mouse IP) -> 20 mg/kg/day (mouse IP); topical 0.68% copper (ex vivo skin)
mixed (molar in vitro, mg/kg animal IP, topical %)
Discuté dans les communautés de recherche* 1-2 mg/day (SC)
Voies d'administration
All doses are preclinical (in vitro molar, ex vivo human skin, rodent topical/IP) and span orders of magnitude across incompatible bases; the only per-kg figures (0.2-20 mg/kg/day IP) are from one mouse emphysema study, two wound studies gave no quantified dose, and there is no established human dosing protocol (first human RCT only recruiting).
- PMID 3169264Maquart FX et al., FEBS Lett 1988 (in vitro fibroblast collagen; 10^-12 to 10^-9 M)
- PMID 15655171Pollard JD et al., Arch Facial Plast Surg 2005 (in vitro irradiated fibroblasts; 1 nM)
- PMID 20703511Hostynek JJ et al., Inflamm Res 2010 (ex vivo human skin; topical 0.68% copper)
- PMID 35936787Zhang Q et al., Front Mol Biosci 2022 (mouse emphysema; 0.2/2/20 mg/kg/day IP)
- PMID 28370978Wang X et al., Wound Repair Regen 2017 (mouse scald; liposomal topical, no dose stated)
- PMID 23744835Parker NP et al., Otolaryngol Head Neck Surg 2013 (rat irradiated flap; topical gel, negative result)
- ClinicalTrials.gov NCT07437586First human RCT: Phase 2 topical wound-healing (recruiting, no results)
Dose utilisée dans les études
0.18 mg/kg/day (180 ug/kg/day) -> 2.5 mg/kg/day
mg/kg/day (animal, in-vivo); nM (in-vitro)
Discuté dans les communautés de recherche* 20-50 mcg/day (SC or IM)
Voies d'administration
All doses are preclinical (pig, rat, guinea pig animal infusions plus in-vitro cell cultures); there is no published human trial or established human protocol for the LR3 analogue.
- PMID 9488001Dunaiski et al. Long [R3] IGF-I reduces growth, plasma GH, IGFBP-3 and endogenous IGF-I in pigs. J Endocrinol. 1997 (pig, 0.18 mg/kg/day IV)
- PMID 8549937Steeb CB, Trahair JF, Read LC. IGF-I peptides stimulate small intestinal epithelium proliferation in rats. Gut. 1995 (rat, 2.5 mg/kg/day SC)
- PMID 7561636Conlon MA et al. Long R3 IGF-I infusion stimulates organ growth but reduces plasma IGF-I/II/IGFBP in the guinea pig. J Endocrinol. 1995 (guinea pig, ~0.34 mg/kg/day SC)
- PMID 15204833Price WA. IGFBP expression alters IGF-mediated proliferation of postnatal lung fibroblasts. Exp Lung Res. 2004 (in vitro, 0.6 nM half-maximal)
- PMID 9096870Duleba AJ et al. Effects of insulin and IGFs on rat ovarian theca-interstitial cell proliferation. Biol Reprod. 1997 (in vitro, concentration not stated)
- PMID 33587816Mongongu C et al. Detection of LongR3-IGF-I for antidoping. Drug Test Anal. 2021 (methods/detection, not efficacy)
Dose utilisée dans les études
1.6 ug/kg (swine ED50, ~0.0016 mg/kg, IV) -> 1.6 mg/kg/day (rat, IV)
mg/kg and ug/kg (mostly animal); human dose also per-kg (0.03 mg/kg)
Discuté dans les communautés de recherche* 200-300 mcg/day (SC)
Voies d'administration
Nearly all doses are preclinical (rat and swine, per-kg); the one human trial used 0.03 mg/kg IV but missed its primary endpoint, so no approved or established human dose exists.
- PMID 9849822Raun K, et al. Ipamorelin, the first selective growth hormone secretagogue. Eur J Endocrinol. 1998;139(5):552-561.
- PMID 25331030Beck DE, Sweeney WB, McCarter MD. Proof-of-concept study of the ghrelin mimetic ipamorelin for postoperative ileus in bowel resection patients. Int J Colorectal Dis. 2014;29(12):1527-1534.
- PMID 19289567Venkova K, et al. Efficacy of ipamorelin in a rodent model of postoperative ileus. J Pharmacol Exp Ther. 2009;329(3):1110-1116.
- PMID 11735244Andersen NB, et al. Ipamorelin counteracts glucocorticoid-induced decrease in bone formation of adult rats. Growth Horm IGF Res. 2001;11(5):266-272.
- PMID 10629165Malmlof K, et al. Methylprednisolone does not inhibit GH release after IV injection of a novel GH secretagogue in rats. Growth Horm IGF Res. 1999;9(6):445-450.
- PMID 12168778Jimenez-Reina L, et al. Chronic ipamorelin treatment in young female rats: somatotroph response in vitro. Histol Histopathol. 2002;17(3):707-714.
Dose utilisée dans les études
16 ug/kg/day (oral, nanoparticle) -> 2.5 mg/kg (oral, proKPV conjugate)
mg/kg (animal)
Discuté dans les communautés de recherche* 250-500 mcg/day (SC)
Voies d'administration
All doses are preclinical (mouse and cell culture) with no established human protocol, and the two clean oral per-kg doses (16 ug/kg to 2.5 mg/kg) both rely on engineered delivery vehicles since free KPV showed little oral benefit on its own.
- PMID 18061177Dalmasso G, et al. PepT1-mediated tripeptide KPV uptake reduces intestinal inflammation. Gastroenterology. 2008;134(1):166-178. (100 micromol/L drinking water; 10-20 nM in vitro; no mg/kg)
- PMID 18092346Kannengiesser K, et al. Melanocortin-derived tripeptide KPV has anti-inflammatory potential in murine models of IBD. Inflamm Bowel Dis. 2008;14(3):324-331. (dose and route not reported)
- PMID 28143741Xiao B, et al. Orally Targeted Delivery of Tripeptide KPV via Hyaluronic Acid-Functionalized Nanoparticles. Mol Ther. 2017;25(7):1628-1640. (16 ug/kg/day oral gavage)
- PMID 23940690Schaible EV, et al. Single Administration of Tripeptide alpha-MSH(11-13) Attenuates Brain Damage after Traumatic Brain Injury in Mice. PLoS One. 2013;8(8):e71056. (1 mg/kg IP single dose)
- PMID 41533788Cheng J, et al. Inflammation-triggered self-immolative conjugates enable oral peptide delivery. Sci Adv. 2026;12(2):eaea2989. (free KPV 1 mg/kg; proKPV 0.5 and 2.5 mg/kg oral)
- PMID 12851308Luger TA, et al. New insights into the functions of alpha-MSH and related peptides in the immune system. Ann N Y Acad Sci. 2003;994:133-140. (mechanism review)
- PMID 15102092Elliott RJ, et al. alpha-MSH, MSH 11-13 KPV and ACTH signalling in human keratinocyte cells. J Invest Dermatol. 2004;122(4):1010-1019. (in vitro human keratinocyte)
Dose utilisée dans les études
less than 10 mcg/mL (in vitro MIC) -> 3.2 mg/mL topical solution (human) / 200 mcg/mL (in vitro MFC)
mixed (mcg/mL in vitro, mg/kg or mcg/mouse in animal, mg/mL topical concentration in human)
Discuté dans les communautés de recherche* 100-300 mcg/day (SC)
Voies d'administration
All figures are research doses used in studies, not a recommendation: in vitro concentrations, small-rodent per-kg or per-mouse doses, and human topical wound concentrations (mg/mL) only, with no approved systemic human protocol and the one adequately powered human trial negative on its primary endpoint.
- PMID 9736536Turner J, et al. Activities of LL-37, a cathelin-associated antimicrobial peptide of human neutrophils. Antimicrob Agents Chemother. 1998 (in vitro, MIC <10 mcg/mL)
- PMID 35205958Rather IA, et al. Antifungal Activity of Human Cathelicidin LL-37 in Candida auris. J Fungi. 2022 (in vitro, MIC 25-100 mcg/mL, MFC 50-200 mcg/mL)
- PMID 17805349Carretero M, et al. In vitro and in vivo wound healing-promoting activities of LL-37. J Invest Dermatol. 2008 (mouse adenoviral, no weighable dose)
- PMID 34680791Simonetti O, et al. Efficacy of LL-37 in an MRSA Wound Infection Mouse Model. Antibiotics. 2021 (mouse, 1 mg/kg topical/IP)
- PMID 26746575Hu Z, et al. LL-37 inhibits pyroptosis of macrophages and improves survival of septic mice. Int Immunol. 2016 (mouse, 2 mcg/mouse IV, ~0.1 mg/kg est.)
- PMID 25041740Gronberg A, et al. Treatment with LL-37 in hard-to-heal venous leg ulcers, Phase I/IIa. Wound Repair Regen. 2014 (human topical, 0.5/1.6/3.2 mg/mL)
- PMID 34687253Mahlapuu M, et al. Evaluation of LL-37 in venous leg ulcers, Phase IIb HEAL. Wound Repair Regen. 2021 (human topical, 0.5/1.6 mg/mL, primary endpoint negative)
Dose utilisée dans les études
0.01 mg/kg (human, SC); 0.05 ng total (rat ICV) -> 6 mg single fixed dose (human case, SC)
mixed (mg/kg human SC, ng total central rat, fixed mg human case)
Discuté dans les communautés de recherche* 250-500 mcg/day (SC)
Voies d'administration
These are doses used in small, dated studies and case reports only (human SC 0.01-0.03 mg/kg, rat central ng doses, a 6 mg toxicity case); there is NO established or validated human dosing protocol, and this is reference information, never a recommendation.
- PMID 8637402Dorr RT, et al. Life Sci. 1996 (Phase I pilot, MT-II pigmentation, 3 men, 0.01-0.03 mg/kg SC)
- PMID 11018622Wessells H, et al. Urology. 2000 (MT-II, organic ED crossover, 10 men, 0.025 mg/kg SC)
- PMID 11035391Wessells H, et al. Int J Impot Res. 2000 (MT-II, ED RigiScan, 20 men, 0.025 mg/kg SC)
- PMID 10904062Murphy B, et al. J Appl Physiol. 2000 (central MTII, rat feeding/temperature, 0.05-500 ng ICV total)
- PMID 23121206Nelson ME, et al. Clin Toxicol (Phila). 2012 (MT-II rhabdomyolysis + AKI, single 6 mg SC case)
- PMID 24334249Schulze F, et al. Eur J Dermatol. 2014 (eruptive/darkening naevi after single MT-II dose, mg not stated)
- PMID 21564053Paurobally D, et al. Melanotan-associated melanoma. Br J Dermatol. 2011 (case report)
- PMID 22724573Ong S, Bowling J. Melanotan-associated melanoma in situ. Australas J Dermatol. 2012 (case report)
Dose utilisée dans les études
0.5 mg/kg/day -> 15 mg/kg
mg/kg (animal)
Discuté dans les communautés de recherche* 5-10 mg/week (SC)
Voies d'administration
Every administered MOTS-c dose is preclinical and intraperitoneal (mouse/rat, 0.5 to 15 mg/kg); the single human study administered nothing (observational serum levels only), so there is no established human protocol.
- PMID 25738459Lee C, et al. MOTS-c promotes metabolic homeostasis and reduces obesity and insulin resistance. Cell Metabolism. 2015.
- PMID 31293078Kim SJ, et al. MOTS-c is a regulator of plasma metabolites and enhances insulin sensitivity. Physiological Reports. 2019.
- PMID 33473109Reynolds JC, et al. MOTS-c is an exercise-induced mitochondrial-encoded regulator of age-dependent physical decline and muscle homeostasis. Nature Communications. 2021.
- PMID 35808870Hyatt JK. MOTS-c increases in skeletal muscle following long-term physical activity and improves acute exercise performance after a single dose. Physiological Reports. 2022.
- PMID 39077591Alser M, et al. The Effect of Chronic Endurance Exercise on Serum Levels of MOTS-c and Humanin in Professional Athletes (observational, no dosing). Reviews in Cardiovascular Medicine. 2022.
- wada-ama.orgWADA Prohibited List: MOTS-c prohibited at all times (S4.4.1, AMPK activator), 2024-2026.
Dose utilisée dans les études
5 mg/kg (rat, IV) -> 750 mg total per infusion (human, IV)
mixed (mg/kg animal; absolute mg human, no per-kg derivable)
Discuté dans les communautés de recherche* 50-100 mg (SC, 2-3x/week)
Voies d'administration
There is no established per-kg human dosing protocol for injected NAD+: the entry states clinic drip doses (250 to 1000 mg) are empirical not validated, no human study reported individual body weights so no per-kg figure exists, and human efficacy data are absent (rat only) while the stronger human evidence is for oral precursors NMN/NR, not intact injected NAD+.
- PMID 31572171Grant R et al., Front Aging Neurosci. 2019 (human IV NAD+ PK, 750 mg/6 h)
- PMID 27648125Zhang Y et al., Am J Transl Res. 2016 (rat IV NAD+, 5/10/20 mg/kg)
- PMID 41704678Reyna K et al., Front Aging. 2026 (human IV NAD+ vs NR tolerability, 500 mg x4 days)
- PMID 35235774Brakedal B et al. NADPARK, Cell Metab. 2022 (human oral NR precursor, 1000 mg/day)
- PMID 35479740Okabe K et al., Front Nutr. 2022 (human oral NMN precursor, 250 mg/day)
- PMID 41357333Wood J et al., NR RCT in long COVID missed primary cognitive endpoint (extra source)
- PMID 40275690Meta-analysis NMN/NR: no muscle-function or frailty benefit over 60 (extra source)
- PMC12907335IV NAD+ vs IV NR tolerability, Front Aging 2026 (extra source)
Dose utilisée dans les études
0.5 mg once weekly (human) -> 12 mg once weekly (human)
mixed (fixed mg/week in human trials; mg/kg per dose in mouse)
Discuté dans les communautés de recherche* 1-2 titrating up to 12 mg/week (SC)
Voies d'administration
All doses are trial-defined research doses (human phase 2/3 weekly 0.5 to 12 mg SC, plus a mouse 30 nmol/kg study); retatrutide is investigational and not EMA/FDA approved, so there is no established human protocol.
- PMID 40094000Marathe SJ, et al. Retatrutide alleviates obesity-associated cancer progression (mouse). NPJ Metab Health Dis. 2025. 30 nmol/kg (~0.14 mg/kg) SC every other day.
- PMID 37366315Jastreboff AM, et al. Retatrutide for Obesity, Phase 2 Trial. NEJM 2023. Weekly 1/4/8/12 mg SC, 48 weeks (n=338).
- PMID 37385280Rosenstock J, et al. Retatrutide in type 2 diabetes, Phase 2. Lancet 2023. Weekly 0.5/4/8/12 mg SC (n=281).
- PMID 38858523Sanyal AJ, et al. Retatrutide for MASLD, Phase 2a. Nat Med 2024. Weekly 1/4/8/12 mg SC (n=98).
- NCT05929066TRIUMPH-1 pivotal Phase 3 obesity trial, top dose 12 mg weekly (n=2339). Lilly topline PR, not peer-reviewed.
Dose utilisée dans les études
5 mg once weekly (human) -> 15 mg once weekly (human)
fixed mg/week (human trials)
Discuté dans les communautés de recherche* 2.5 titrating up to 15 mg/week (SC)
Voies d'administration
Trial-defined research doses (human phase 3: 5/10/15 mg once weekly SC, escalated from 2.5 mg). Tirzepatide is an approved prescription medicine in some markets; we supply it strictly as a research-grade material, not as a human protocol.
- PMID 35658024Jastreboff AM, et al. Tirzepatide Once Weekly for Obesity (SURMOUNT-1). NEJM 2022. Weekly 5/10/15 mg SC, 72 weeks (n=2539).
- PMID 34170647Frias JP, et al. Tirzepatide vs Semaglutide in Type 2 Diabetes (SURPASS-2). NEJM 2021. Weekly 5/10/15 mg SC, 40 weeks (n=1879).
- PMID 34186022Rosenstock J, et al. Tirzepatide monotherapy, Type 2 Diabetes (SURPASS-1). Lancet 2021. Weekly 5/10/15 mg SC, 40 weeks (n=478).
- PMID 38856224Loomba R, et al. Tirzepatide for MASH (SYNERGY-NASH). NEJM 2024. Weekly 5/10/15 mg SC, 52 weeks (n=190).
Dose utilisée dans les études
0.3 mg/kg (300 ug/kg, animal) -> 0.3 mg/kg (300 ug/kg, animal)
mg/kg (animal); human absolute dose not stated in abstracts; in-vitro 100 nM
Discuté dans les communautés de recherche* 250-500 mcg/day (intranasal)
Voies d'administration
The only clean numeric dose is the animal 0.3 mg/kg (300 ug/kg); the human trials report no derivable dose and Selank has no approved human protocol outside Russia/Ukraine.
- PMID 18454096Zozulia AA et al. Efficacy and possible mechanisms of a new peptide anxiolytic selank in GAD and neurasthenia. Zh Nevrol Psikhiatr. 2008 (human GAD vs medazepam, intranasal, ~14 days; no absolute dose in abstract)
- PMID 28280289Kasian A et al. Selank Enhances the Effect of Diazepam in UCMS in Rats. Behav Neurol. 2017 (rat, 0.3 mg/kg intranasal, 14 days)
- PMID 29787664Vasil'eva EV et al. Selank intranasal vs intraperitoneal in BALB/c and C57BL/6 mice. Eksp Klin Farmakol. 2016 (mouse, 0.3 mg/kg/day, 5 days)
- PMID 30255741Vyunova TV et al. Molecular Aspects of Heptapeptide Selank Biological Activity. Protein Pept Lett. 2018 (in-vitro GABA radioligand binding, concentration series)
- PMID 18577961Uchakina ON et al. Immunomodulatory effects of selank in anxiety-asthenic disorders. Zh Nevrol Psikhiatr. 2008 (human 14 days + in-vitro 10^-7 M; no in-vivo dose in abstract)
- PMID 28702721Slominsky PA et al. Semax and selank in 6-OHDA PD-like rats. Dokl Biol Sci. 2017 (largely null behavioral result)
- PMID 18841804Inozemtseva LS et al. Intranasal Selank regulates BDNF in rat hippocampus. Dokl Biol Sci. 2008 (dose not in abstract)
Dose utilisée dans les études
0.045 mg/kg (60 nmol/kg, rat IP) -> 0.25 mg/kg (250 ug/kg, rat intranasal)
mixed (animal mg/kg per-kg; human absolute mg/day, no weight; in vitro molar)
Discuté dans les communautés de recherche* 300-600 mcg/day (intranasal)
Voies d'administration
Best-quantified doses are preclinical rat studies (0.045-0.25 mg/kg intranasal or IP); the only human data is a small, old, non-randomized stroke trial giving 12-18 mg/day intranasal with no body weight, so no established or approved human protocol exists.
- PMID 11517472Gusev/Skvortsova 1997, human acute ischemic stroke, 12-18 mg/day intranasal
- PMID 16996037Dolotov 2006, rat hippocampus BDNF/trkB, 50 ug/kg intranasal
- PMID 16635254Dolotov 2006, rat basal forebrain BDNF, 50 and 250 ug/kg intranasal
- PMID 17603664Romanova 2006, rat cortical ischemia, 250 ug/kg/day intranasal x6d
- PMID 39442746Inozemtseva 2024, rat chronic stress, 60 nmol/kg (~0.045 mg/kg) IP daily
- PMID 18431004Grivennikov 2008, rat basal forebrain neurons in vitro, 100 nM (1 nM-10 microM range)
- PMID 19662538Shadrina 2010, rat NGF/BDNF gene expression (extra source)
- PMID 11569188Kurysheva/Shpak 2001, human glaucomatous optic neuropathy, topical/electrophoresis (extra source)
Dose utilisée dans les études
1 mcg/kg (single IV diagnostic bolus) -> 60 mcg/kg/day SC (0.060 mg/kg/day); separately 1.0 mg absolute per injection in the older-men study
mixed: mcg/kg per-kg (human pediatric studies) plus absolute mg (adult study, no reported weight)
Discuté dans les communautés de recherche* 200-300 mcg (SC, evening)
Voies d'administration
Unusually for this catalog, sermorelin (Geref) had an FDA-approved human protocol, and the pediatric GH-deficiency dose of 30 mcg/kg/day SC once daily is an established human dose; all figures here are doses used in studies, not a recommendation.
- PMID 8772599Thorner M, et al. Once daily subcutaneous GHRH therapy accelerates growth in GH-deficient children (Geref Study Group). J Clin Endocrinol Metab. 1996 (30 mcg/kg/day SC)
- PMID 7955460Kirk JM, et al. GHRH(1-29)NH2 in children with idiopathic short stature. Clin Endocrinol (Oxf). 1994 (20 mcg/kg SC twice daily)
- PMID 8329826Neyzi O, et al. Growth response to GHRH(1-29)-NH2 compared with GH. Acta Paediatr Suppl. 1993 (30 or 60 mcg/kg/day SC)
- PMID 2880720Ranke MB, et al. Testing with GRF(1-29)NH2 for evaluation of GH deficiency. Eur J Pediatr. 1986 (1 mcg/kg single IV diagnostic bolus)
- PMID 8329828Hummelink R, et al. Intranasal GHRH(1-29)-NH2 in children with GH deficiency. Acta Paediatr Suppl. 1993 (50 mcg/kg intranasal three times daily)
- PMID 1379256Corpas E, et al. GHRH-(1-29) twice daily reverses decreased GH and IGF-I in old men. J Clin Endocrinol Metab. 1992 (0.5 mg and 1.0 mg absolute SC)
- PMID 8329830Chen RG, et al. Companion GHRH vs GH growth analyses. Acta Paediatr Suppl. 1993 (extra source)
Dose utilisée dans les études
0.005 mg/kg/h (IV, lowest human cohort) -> 0.25 mg/kg/h IV; 40 mg/day SC (human); 3 mg/kg/day SC (mouse)
mixed: per-kg for IV cohorts and mouse (mg/kg/h, mg/kg/day); fixed mg/day for SC human trials where body weight was not reported
Discuté dans les communautés de recherche* 1-2 (up to 5-10) mg/day (SC)
Voies d'administration
All doses shown are the doses used in the cited trials, not a recommendation; the pivotal human efficacy trials mostly failed their primary endpoints, and the only human approval (FDA FORZINITY, Sep 2025) is narrow to Barth syndrome, so there is no established human protocol for the longevity/cardiac/AMD uses studied here.
- PMID 29217757Daubert MA, et al. Elamipretide in HFrEF (RCT). Circ Heart Fail. 2017;10(12):e004389. IV 0.005-0.25 mg/kg/h.
- PMID 29500292Karaa A, et al. Dose-escalation elamipretide in primary mitochondrial myopathy. Neurology. 2018;90(14):e1212. IV 0.01-0.25 mg/kg/h.
- PMID 32096613Karaa A, et al. MMPOWER-2 crossover, primary mitochondrial myopathy. J Cachexia Sarcopenia Muscle. 2020;11(4):909. SC 40 mg/day (~0.61 mg/kg/day).
- PMID 32068002Butler J, et al. PROGRESS-HF Phase 2, HFrEF. J Card Fail. 2020;26(5):429. SC 4 and 40 mg/day.
- PMID 36246181Mettu PS, et al. ReCLAIM Phase 1 dry AMD (open-label). Ophthalmol Sci. 2022;2(1):100086. SC 40 mg/day.
- PMID 32648542Chiao YA, et al. SS-31 reverses cardiac dysfunction in old mice. eLife. 2020;9:e55513. SC 3 mg/kg/day (minipump).
- PMID 41260682FDA accelerated approval of elamipretide (FORZINITY) for Barth syndrome only, Sep 2025 (surrogate endpoint).
- PMID 37268435Karaa A, et al. MMPOWER-3 Phase 3 (missed co-primary endpoints). Neurology. 2023.
- PMID 26839394Sabbah HN, et al. Chronic elamipretide in dogs with advanced HF. Circ Heart Fail. 2016;9(2):e002206. SC 0.5 mg/kg/day.
Dose utilisée dans les études
1.6 mg/kg/day (mouse, IP); topical amounts as low as 5 mcg/drop; in vitro active at 10 pg -> 6 mg/kg (pig, IV)
mixed: mg/kg (systemic, animal) plus absolute mcg (topical/ocular); no human systemic dose
Discuté dans les communautés de recherche* 4-8 mg/week (SC)
Voies d'administration
These are doses used in published studies (mostly mouse/rat/pig and one small human eye-drop trial), spanning several orders of magnitude across routes, not a recommendation; there is no approved or validated human systemic dosing protocol.
- PMID 25015963Peng H, et al. Thymosin-beta4 prevents cardiac rupture and improves cardiac function in mice with myocardial infarction. Am J Physiol Heart Circ Physiol. 2014. (mouse, 1.6 mg/kg/day IP)
- PMID 27199757Stark C, et al. Systemic Dosing of Thymosin Beta 4 before and after Ischemia Does Not Attenuate Global Myocardial Ischemia-Reperfusion Injury in Pigs. Front Pharmacol. 2016. (pig, 6 mg/kg IV, NEGATIVE)
- PMID 25826322Sosne G, Dunn SP, Kim C. Thymosin beta4 significantly improves signs and symptoms of severe dry eye in a phase 2 randomized trial. Cornea. 2015. (human, topical 0.1% RGN-259, ~50 mcg/drop, n=9)
- PMID 11950239Sosne G, et al. Thymosin beta 4 promotes corneal wound healing and decreases inflammation in vivo following alkali injury. Exp Eye Res. 2002. (mouse, 5 mcg/dose topical)
- PMID 25230158Kim S, Kwon J. Thymosin beta 4 improves dermal burn wound healing via downregulation of RAGE in db/db mice. Biochim Biophys Acta. 2014. (mouse, 5 mg/kg intradermal)
- PMID 10469335Malinda KM, et al. Thymosin beta4 accelerates wound healing. J Invest Dermatol. 1999. (rat topical+IP; no mg/kg reported; in vitro active at 10 pg)
- PMID 15565145Bock-Marquette I, et al. Thymosin beta4 activates integrin-linked kinase and promotes cardiac cell migration, survival and cardiac repair. Nature. 2004. (foundational mechanism; dosing not in abstract)
- DOI 10.1093/cvr/cvaf223, NCT05984134First-in-human recombinant thymosin beta-4 (rhTB4) trial in STEMI: overall negative on infarct size. Cardiovascular Research. 2025.
- RegeneRx SEER-3 topline 2025RGN-259 (thymosin beta-4 ophthalmic) SEER-3 trial 2025 missed its primary corneal-healing endpoint.
Dose utilisée dans les études
2 mg/day (human, fixed, ~0.02 mg/kg/day) -> 600 ug/kg (0.6 mg/kg, animal)
mixed: fixed 2 mg/day (human) and mg/kg (animal preclinical)
Discuté dans les communautés de recherche* 1-2 mg/day (SC)
Voies d'administration
Unlike most research peptides, tesamorelin has a regulator-approved human dose (FDA Egrifta, 2 mg subcutaneous once daily), but every human trial was in HIV-associated fat accumulation and the per-kg figures are weight-estimates since the papers reported only BMI.
- PMID 18057338Falutz et al., N Engl J Med, 2007 (NEJM phase III, 26-week, 2 mg/day SC)
- PMID 20101189Falutz et al., J Acquir Immune Defic Syndr, 2010 (12-month with safety extension, 2 mg/day SC)
- PMID 20554713Falutz et al., J Clin Endocrinol Metab, 2010 (second phase III, 806 patients, 2 mg/day SC)
- PMID 25038357Stanley et al., JAMA, 2014 (liver-fat mechanistic RCT, 2 mg/day SC)
- PMID 31611038Stanley et al., Lancet HIV, 2019 (NAFLD RCT, 2 mg/day SC)
- PMID 17214611Ferdinandi et al., Basic Clin Pharmacol Toxicol, 2007 (preclinical pigs/rats/dogs, up to 600 ug/kg IV+SC)
- PMID 22050344Dhillon, BioDrugs, 2011 (review, pooled two 26-week trials)
- PMID 41545261Badran et al., Obes Res Clin Pract, 2026 (meta-analysis of 5 RCTs)
Dose utilisée dans les études
10 mg/day (human, IM) -> 10 mg/day (human, IM)
fixed mg (human, absolute daily dose); animal and in vitro doses not reported
Discuté dans les communautés de recherche* 10 mg/day (IM or SC)
Voies d'administration
The only numeric study dose is an absolute 10 mg/day IM in two Russian human studies (no body weight reported, so mg/kg cannot be derived); the rat and in vitro doses are not recoverable, and thymalin is not an approved drug in the EU/US, so no established human protocol exists.
- PMID 33575961Khavinson VK, Kuznik BI, Trofimova SV, et al. COVID-19 complex therapy (human, severe COVID-19, 10 mg/day IM x5d). Stem Cell Rev Rep. 2021;17(1):285-290.
- PMID 12577695Khavinson VKh, Morozov VG. Geroprotective effect of thymalin and epithalamin (human, 266-person elderly cohort). Adv Gerontol. 2002;10:74-84.
- PMID 29797130Zhukova GV, et al. Effect of Thymalin on the Tumor and Thymus under Activation Therapy In Vivo (rat sarcoma 45, dose qualitative only). Bull Exp Biol Med. 2018;165(1):80-83.
- PMID 33237528Khavinson VK, Linkova NS, et al. Thymalin: Activation of Differentiation of Human Hematopoietic Stem Cells (in vitro, concentration not recoverable). Bull Exp Biol Med. 2020;170(1):118-122.
- PMID 14523363Khavinson VKh, Morozov VG. Peptides of pineal gland and thymus prolong human life (companion report, same 266-person cohort). Neuro Endocrinol Lett. 2003;24(3-4):233-240.
- PMID 11163623Anisimov VN, et al. Synthetic thymic/pineal peptides in CBA mice (tests dipeptide Lys-Glu, NOT thymalin extract; SC 0.1 ug/animal/month, ~3.3-4 ug/kg). Mech Ageing Dev. 2001;122(1):41-68.
Dose utilisée dans les études
900 mcg/m2 per dose (BSA-based) -> 1.6 mg per dose
fixed absolute per dose (mg); one study per body-surface-area (mcg/m2); no trial-reported mg/kg
Discuté dans les communautés de recherche* 1.5-1.6 mg (SC)
Voies d'administration
These are doses used in published human trials (reference only, not a recommendation); a standard 1.6 mg twice-weekly subcutaneous regimen exists for the approved drug thymalfasin/Zadaxin, though the strongest recent endpoints (sepsis, hepatitis B/C) were largely negative.
- PMID 39814420Wu J, et al. TESTS phase 3 sepsis trial. BMJ. 2025.
- PMID 23327199Wu J, et al. ETASS severe sepsis trial. Crit Care. 2013.
- PMID 22233415Ciancio A, et al. Thymosin alpha-1 add-on for chronic hepatitis C. J Viral Hepat. 2012.
- PMID 10607256Mutchnick MG, et al. Phase III chronic hepatitis B trial. J Viral Hepat. 1999.
- PMID 2642497Gravenstein S, et al. Influenza antibody response in elderly men. J Am Geriatr Soc. 1989.
- PMID 36881981Tuthill CW, et al. Thymalfasin pilot in renal dialysis (COVID-19). Int Immunopharmacol. 2023.
* Référence issue de forums de peptides et de discussions communautaires. Ce n'est ni une recommandation, ni basé sur des études, ni un protocole humain établi.
Sélectionnez un peptide, consultez la dose utilisée dans les études, puis calculez le volume de la seringue : Calculer le volume de la seringue -> · Détails complets des études dans la référence des études ->
