Tesamorelin is a stabilized GHRH analog consisting of the full 44-amino-acid GHRH sequence with an N-terminal trans-3-hexenoic acid modification. This modification protects against DPP-IV enzymatic cleavage, significantly extending its half-life.

How should I store Tesamorelin?

Store lyophilized Tesamorelin at -20°C for long-term storage or at 2-8°C for short-term use. Reconstitute with bacteriostatic water and use within 30 days. Keep refrigerated at 2-8°C after reconstitution.

What purity is your Tesamorelin?

Our Tesamorelin is independently tested by Janoshik Analytical at a minimum of 98% HPLC purity. Each batch comes with a certificate of analysis accessible on the product page.

How is Tesamorelin different from Sermorelin?

Tesamorelin is a full GHRH(1-44) analog with an N-terminal fatty acid stabilizer, giving it a much longer half-life than Sermorelin GHRH(1-29). Tesamorelin is the only GHRH analog with FDA approval, used in HIV-related lipodystrophy research.

Buy Tesamorelin Peptide ≥98% Purity

Name: Tesamorelin
Brand: PeptidesDirect
SKU: PD-TESAMORELIN-10MG
Price: 69.99 EUR
Availability: InStock

GHRH analog

Tesamorelin is a synthetic 44 amino acid analog of growth hormone releasing hormone, with an N-terminal modification that resists rapid breakdown by DPP-4.

Pulsatile GH release

Binds GHRH receptors on pituitary somatotrophs and triggers natural, pulsatile growth hormone secretion rather than a flat exogenous spike.

Visceral fat focus

Studied in clinical trials for selective reduction of visceral adipose tissue while sparing subcutaneous fat and lean mass.

IGF-1 axis modulation

Increases circulating IGF-1 through downstream hepatic stimulation, restoring a youthful pattern of the GH and IGF-1 axis in research models.

Liver fat research

Shifts hepatic gene expression toward oxidative phosphorylation and away from inflammation in HIV-associated NAFLD trials.

Cognitive aging research

GHRH stimulation has been studied for its effects on executive function and verbal memory in older adults, including those with mild cognitive impairment.

Research areas

Visceral fatGH and IGF-1 axisLiver metabolismCognitive agingLipodystrophy

What is Tesamorelin

Tesamorelin is a synthetic 44 amino acid peptide that mirrors human growth hormone releasing hormone (GHRH). A small chemical group (trans-3-hexenoic acid) is added to the N-terminus, which protects the molecule from the enzyme DPP-4 and gives it a much longer working half-life than natural GHRH. It is the first and so far only compound approved by the FDA for the reduction of excess abdominal fat in HIV-associated lipodystrophy, sold under the brand name Egrifta.

We supply it in lyophilized (freeze-dried) form, the same molecule used in the published clinical and laboratory studies.

How it works

Tesamorelin docks onto GHRH receptors on somatotroph cells in the anterior pituitary. The receptor activates an intracellular calcium and cAMP cascade, prompting the cell to synthesize and release growth hormone in the natural pulsatile rhythm. The released GH then travels to the liver and other tissues, where it triggers production of insulin-like growth factor 1 (IGF-1).

The most documented effect is on visceral adipose tissue. In randomized trials in HIV-associated lipodystrophy, tesamorelin reduced visceral fat by roughly 15 to 18 percent over 26 weeks, while subcutaneous fat and lean tissue were preserved. Follow-up work has shown reductions in liver fat in HIV-associated non-alcoholic fatty liver disease and a shift in hepatic gene expression toward oxidative phosphorylation and away from inflammation. Because the GHRH system feeds back on itself, the pulsatile pattern of GH release remains close to physiological, which separates this approach from direct exogenous GH administration in research models.

A separate line of research has examined GHRH stimulation in cognitive aging. In a 20-week controlled trial in older adults, GHRH treatment raised IGF-1 and produced favorable effects on executive function, with positive trends in verbal memory in both healthy older adults and those with mild cognitive impairment. The cognitive findings in HIV cohorts have been more mixed.

Often studied alongside

Published tesamorelin trials have been monotherapy, but some researchers in community protocols pair it with growth hormone releasing peptides (GHRPs) such as ipamorelin, which act on a different receptor (GHSR) and amplify GH release through a complementary pathway. Sermorelin, the shorter 29 amino acid GHRH fragment, is often used as a lower-cost alternative when long half-life is not required.

Shorter GHRH fragment in the same receptor family

Sermorelingrowth

GHRH(1-29) analog for physiological growth hormone stimulation research

Combined GHRH and GHRP research blend

CJC-1295/Ipamorelin (No-DAC)growth

2-in-1 growth hormone blend: CJC-1295 no-DAC (Modified GRF 1-29, 5 mg) + Ipamorelin (5 mg) combined in one vial. The CJC-1295 component is the short-acting no-DAC variant (about 30 minute half-life), not the long-acting DAC form. Stimulates natural GH release through two different pathways for amplified, more physiological growth hormone pulses.

For reconstitution, the standard solvent in published protocols is bacteriostatic water. The dissolved peptide is clear and colorless.

Standard solvent for reconstitution

Bacteriostatic Wateraccessories

USP-grade sterile water with 0.9% benzyl alcohol - the standard solvent for reconstituting lyophilized peptides. Essential accessory for any peptide research. Each vial is sealed and ready to use.

Documentation

Material specification

Purity

≥98% (HPLC verified)

Test method

HPLC + mass spectrometry

Form

Lyophilized powder

Storage (sealed)

2 to 8 °C, light-protected

Storage (reconstituted)

2 to 8 °C, use within 4 weeks

CoA

Batch-specific, third-party (Janoshik)

Lab Report (COA)

Batch NumberRed

Purity99.36%

Testing LabJanoshik

Test Date30 Oct 2025

Download COA

Selected research

Research use only

This material is sold strictly for in-vitro research and laboratory use. Not intended for human or animal consumption, medical, cosmetic, or household applications. Suitable only for professional laboratory environments.